ypoglycemia, Defective Islet Glucagon Secretion, but Normal slet Mass in Mice With a Disruption of the Gastrin Gene OBIN P. BOUSHEY,* AMIR ABADIR,* DAISY FLAMEZ,‡ LAURIE L. BAGGIO,* YAZHOU LI,* EERLE BERGER,‡ BESS A. MARSHALL,§ DIANE FINEGOOD,
نویسندگان
چکیده
OBIN P. BOUSHEY,* AMIR ABADIR,* DAISY FLAMEZ,‡ LAURIE L. BAGGIO,* YAZHOU LI,* EERLE BERGER,‡ BESS A. MARSHALL,§ DIANE FINEGOOD, TIMOTHY C. WANG,¶ FRANS SCHUIT,‡ nd DANIEL J. DRUCKER* Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada; Diabetes Research Center, Faculty of Medicine, Vrije Universiteit Brussels, Brussels, Belgium; §Department of Pediatrics, Saint Louis hildren’s Hospital at Washington University School of Medicine, St. Louis, Missouri; School of Kinesiology, Simon Fraser University, British olumbia, Canada; and ¶Department of Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts
منابع مشابه
Therapeutic approaches to preserve islet mass in type 2 diabetes.
Type 2 diabetes is characterized by hyperglycemia resulting from insulin resistance in the setting of inadequate beta-cell compensation. Currently available therapeutic agents lower blood glucose through multiple mechanisms but do not directly reverse the decline in beta-cell mass. Glucagon-like peptide-1 (GLP-1) receptor agonists, exemplified by Exenatide (exendin-4), not only acutely lower bl...
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Glucagon-like peptide-1 (GLP-1) regulates energy intake, gastrointestinal motility, and nutrient disposal. The relative importance of the islet beta-cell for GLP-1 actions remains unclear. We determined the role of the islet beta-cell and the pancreatic duodenal homeobox-1 (Pdx1) transcription factor for GLP-1 receptor (GLP-1R)-dependent actions through analysis of mice with beta-cell-specific ...
متن کاملIslet function phenotype in gastrin-releasing peptide receptor gene-deficient mice.
Gastrin-releasing peptide (GRP) is an islet neuropeptide that stimulates insulin secretion. To explore whether islet GRP contributes to neurally mediated insulin secretion, we studied GRP receptor (GRPR)-deleted mice. By using RT-PCR we showed that GRPR mRNA is expressed in islets of wild-type mice, but is lost in GRPR-deleted mice. Functional studies revealed that GRP potentiates glucose-stimu...
متن کاملCombination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice
OBJECTIVE Glucagon-like peptide-1 (GLP-1) and gastrin promote pancreatic beta-cell function, survival, and growth. Here, we investigated whether GLP-1 and gastrin can restore the beta-cell mass and reverse hyperglycemia in NOD mice with autoimmune diabetes. RESEARCH DESIGN AND METHODS Acutely diabetic NOD mice were treated with GLP-1 and gastrin, separately or together, twice daily for 3 week...
متن کاملThe Novel GLP-1–Gastrin Dual Agonist ZP3022 Improves Glucose Homeostasis and Increases b-Cell Mass without Affecting Islet Number in db/db Mice
Antidiabetic treatments aiming to preserve or even to increase b-cell mass are currently gaining increased interest. Here we investigated the effect of chronic treatment with the novel glucagon-like peptide-1 (GLP-1)–gastrin dual agonist ZP3022 (HGEGTFTSDLSKQMEEEAVRLFIEWLKN-8Ado-8Ado-YGWLDFNH2) on glycemic control, b-cell mass and proliferation, and islet number. Male db/db mice were treated wi...
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